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KMID : 0363819770110010003
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Korean Journal of Nuclear Medicine
1977 Volume.11 No. 1 p.3 ~ p.8
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Alteration of Hemorrhagic Aldosterone Response During Sodium Restriction, Potassium Supplement and Diuresis
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성호경/Sung, Ho Kyung
유용운/고주환/박귀원/이장규/Ryu, Yong Wun/Koh, Joo Hwan/Park, Kee Won/Lee, Jang Kyu
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Abstract
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Effect of sodium restriction with or without potassium supplement and furosemide diuresis on plasma aldosterone response to mild hemorrhage were studied in normotensive young volunteers.
After an overnight fast, blood were drawn just before and 10, 20, 30, 50, 70, 90, and 120 minutes after the 3H-aldosterone injection. The sum of blood delivered reached over 100ml(during two hours;. Plasma aldosterone and renin were measured by means of radioimmunoassay.
The results were as followed;
1. Hemorrhage resulted in a moderate increase in plasma aldosterone level of volunteers with normal diet.
2. The mean figures of plasma aldosterone in subjects with sodium restriction and diuresis were likewise significantly increased by hemorrhage, however, the figure of the subjects with potassium supplement who already shown higher plasma level was without effect on hemorrhage.
3. Hemorrhage produced slight decrease in serum sodium concentration in every experimental conditions, although the changes were not significant.
4. Plasma renin activities after the hemorrhage followed a similar patte n with that of aldos terone, increased during sodium restriction or diuresis and unaffected during potassium supplement.
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